Premature Age-Related Comorbidities Among HIV-Infected Persons Compared With the General Population, Giovanni Guaraldi et al., Clinical Infectious Diseases Advance Access (2011)

This article examines the frequency of noninfectious comorbidities (NICMs), including cardiovascular disease, hypertension, diabetes mellitus, bone fractures, and renal failure, in people living with HIV compared with the general population. The authors of the study found that people living with HIV were more likely to experience these health problems at an earlier age than people without HIV. People with HIV, aged 41 to 50 years, had a similar likelihood of experiencing two or more concurrent NICMs as did people without HIV, aged 51 to 60, illustrating the apparent premature aging effects of HIV. The factors that could readily account for the occurrence of multiple traditionally age-related NICMs at significantly earlier ages among people with HIV are not immediately apparent. However, the authors urge earlier screening for NICMs in people with HIV based on these findings.